Neuronal control of maternal provisioning in response to social cues

Wasson, Jadiel A. and Harris, Gareth and Keppler-Ross, Sabine and Brock, Trisha J. and Dar, Abdul R. and Butcher, Rebecca A. and Fischer, Sylvia E. J. and Kagias, Konstantinos and Clardy, Jon and Zhang, Yun and Mango, Susan E.. (2021) Neuronal control of maternal provisioning in response to social cues. Science Advances, 7 (34). eabf8782.

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Mothers contribute cytoplasmic components to their progeny in a process called maternal provisioning. Provisioning is influenced by the parental environment, but the molecular pathways that transmit environmental cues between generations are not well understood. Here, we show that, in; Caenorhabditis elegans; , social cues modulate maternal provisioning to regulate gene silencing in offspring. Intergenerational signal transmission depends on a pheromone-sensing neuron and neuronal FMRFamide (Phe-Met-Arg-Phe)-like peptides. Parental FMRFamide-like peptide signaling dampens oxidative stress resistance and promotes the deposition of mRNAs for translational components in progeny, which, in turn, reduces gene silencing. This study identifies a previously unknown pathway for intergenerational communication that links neuronal responses to maternal provisioning. We suggest that loss of social cues in the parental environment represents an adverse environment that stimulates stress responses across generations.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development
05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Mango)
UniBasel Contributors:Mango, Susan Elizabeth and Wasson, Jadiel Ahneva
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:07 Sep 2021 10:34
Deposited On:07 Sep 2021 10:34

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