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PET/CT-Based Response Evaluation in Cancer-a Systematic Review of Design Issues

Gerke, Oke and Ehlers, Karen and Motschall, Edith and Høilund-Carlsen, Poul Flemming and Vach, Werner. (2020) PET/CT-Based Response Evaluation in Cancer-a Systematic Review of Design Issues. Molecular imaging and biology, 22 (1). pp. 33-46.

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Official URL: https://edoc.unibas.ch/84158/

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Abstract

Positron emission tomography/x-ray computed tomography (PET/CT) has long been discussed as a promising modality for response evaluation in cancer. When designing respective clinical trials, several design issues have to be addressed, especially the number/timing of PET/CT scans, the approach for quantifying metabolic activity, and the final translation of measurements into a rule. It is unclear how well these issues have been tackled in quest of an optimised use of PET/CT in response evaluation. Medline via Ovid and Science Citation Index via Web of Science were systematically searched for articles from 2015 on cancer patients scanned with PET/CT before and during/after treatment. Reports were categorised as being either developmental or evaluative, i.e. focusing on either the establishment or the evaluation of a rule discriminating responders from non-responders. Of 124 included papers, 112 (90 %) were accuracy and/or prognostic studies; the remainder were response-curve studies. No randomised controlled trials were found. Most studies were prospective (62 %) and from single centres (85 %); median number of patients was 38.5 (range 5-354). Most (69 %) of the studies employed only one post-baseline scan. Quantification was mainly based on SUVmax (91 %), while change over time was most frequently used to combine measurements into a rule (79 %). Half of the reports were categorised as developmental, the other half evaluative. Most development studies assessed only one element (35/62, 56 %), most frequently the choice of cut-off points (25/62, 40 %). In summary, the majority of studies did not address the essential open issues in establishing PET/CT for response evaluation. Reasonably sized multicentre studies are needed to systematically compare the many different options when using PET/CT for response evaluation.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Integrative Biologie > Integrative Prähistorische und Naturwissenschaftliche Archäologie (IPNA)
UniBasel Contributors:Vach, Werner
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1860-2002
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 Feb 2022 07:02
Deposited On:03 Feb 2022 07:02

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