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Association between IL-8 (-251T/A) and IL-6 (-174G/C) Polymorphisms and Oral Cancer Susceptibility: A Systematic Review and Meta-Analysis

Rezaei, Farzad and Mohammadi, Hady and Heydari, Mina and Sadeghi, Masoud and Mozaffari, Hamid Reza and Khavid, Atefeh and Godiny, Mostafa and Brand, Serge and M. Dürsteler, Kenneth and Beatrix Brühl, Annette and Cordier, Dominik and Sadeghi-Bahmani, Dena. (2021) Association between IL-8 (-251T/A) and IL-6 (-174G/C) Polymorphisms and Oral Cancer Susceptibility: A Systematic Review and Meta-Analysis. Medicina, 57 (5). p. 405.

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Abstract

Inflammation and cell-mediated immunity can have significant roles in different stages of carcinogenesis. The present meta-analysis aimed to evaluate the association between the polymorphisms of; IL-8 (-251T/A); and; IL-6 (-174G/C); and the risk of oral cancer (OC).; PubMed/MEDLINE, Web of Science, Cochrane Library, and Scopus databases were searched until December 18, 2020 without any restrictions. RevMan 5.3 software was used to calculate the results of forest plots (odds ratios (ORs) and 95% confidence intervals (CIs)); CMA 2.0 software was used to calculate funnel plots (Begg's and Egger's tests), and SPSS 22.0 was used for the meta-regression analysis. Moreover, trial sequential analysis was conducted to estimate the robustness of the results.; Eleven articles including twelve studies were selected for the meta-analysis. The pooled ORs for the association between; IL-8 (-251T/A); polymorphism and the risk of OC in the models of A vs. T, AA vs. TT, TA vs. TT, AA + TA vs. TT, and AA vs. TT + TA were 0.97 (; p; = 0.78), 0.86 (; p; = 0.55), 0.78 (; p; = 0.37), 0.83 (; p; = 0.45), and 1.10 (; p; = 0.34), respectively. The pooled ORs; IL-6 (-174G/C); polymorphism and the risk of OC in the models of C vs. G, CC vs. GG, GC vs. GG, CC + GC vs. GG, and CC vs. GG + GC were 1.07 (; p; = 0.87), 1.17 (; p; = 0.82), 1.44 (; p; = 0.38), 1.28 (; p; = 0.61), and 0.96 (; p; = 0.93), respectively. There was no association between; IL-8 (-251T/A); polymorphism and OC susceptibility, but the C allele and GC and CC genotypes of; IL-6 (-174G/C); polymorphism were associated with the risk of OC based on subgroup analyses, that is to say, the source of control and the genotyping method might bias the pattern of association.; The meta-analysis confirmed that there was no association between the polymorphisms of; IL-6 (-174G/C); and; IL-8 (-251T/A); and the susceptibility of OC. However, the source of control and the genotyping method could unfavorably impact on the association between the polymorphisms of; IL-6 (-174G/C); and the risk OC.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sportwissenschaft > Sportwissenschaften (Pühse)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Persönlichkeits- und Entwicklungspsychologie > Entwicklungs- und Persönlichkeitspsychologie (Grob)
UniBasel Contributors:Brand, Serge
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:MDPI
e-ISSN:1648-9144
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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edoc DOI:
Last Modified:06 Jul 2021 08:54
Deposited On:06 Jul 2021 08:54

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