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A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder

Ghafouri-Fard, Soudeh and Badrlou, Elham and Taheri, Mohammad and Dürsteler, Kenneth M. and Beatrix Brühl, Annette and Sadeghi-Bahmani, Dena and Brand, Serge. (2021) A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder. International Journal of Molecular Siences, 22 (10). p. 5156.

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Abstract

Bipolar disorder is a multifactorial disorder being linked with dysregulation of several genes. Among the recently acknowledged factors in the pathophysiology of bipolar disorder are non-coding RNAs (ncRNAs).; We searched PubMed and Google Scholar databases to find studies that assessed the expression profile of miRNAs, lncRNAs and circRNAs in bipolar disorder.; Dysregulated ncRNAs in bipolar patients have been enriched in several neuron-related pathways such as GABAergic and glutamatergic synapses, morphine addiction pathway and redox modulation.; Altered expression of these transcripts in bipolar disorder provides clues for identification of the pathogenesis of this disorder and design of targeted therapies for the treatment of patients.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Klinische Stress- und Traumaforschung (Holsboer-Trachsler)
03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sportwissenschaft > Sportwissenschaften (Pühse)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Persönlichkeits- und Entwicklungspsychologie > Entwicklungs- und Persönlichkeitspsychologie (Grob)
UniBasel Contributors:Brand, Serge
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:MDPI
ISSN:1661-6596
e-ISSN:1422-0067
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
edoc DOI:
Last Modified:06 Jul 2021 08:39
Deposited On:06 Jul 2021 08:39

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