Learning the space-time phase diagram of bacterial swarm expansion

Jeckel, Hannah and Jelli, Eric and Hartmann, Raimo and Singh, Praveen K. and Mok, Rachel and Totz, Jan Frederik and Vidakovic, Lucia and Eckhardt, Bruno and Dunkel, Jörn and Drescher, Knut. (2019) Learning the space-time phase diagram of bacterial swarm expansion. Proceedings of the National Academy of Sciences of the United States of America, 116 (5). pp. 1489-1494.

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Official URL: https://edoc.unibas.ch/83579/

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Coordinated dynamics of individual components in active matter are an essential aspect of life on all scales. Establishing a comprehensive, causal connection between intracellular, intercellular, and macroscopic behaviors has remained a major challenge due to limitations in data acquisition and analysis techniques suitable for multiscale dynamics. Here, we combine a high-throughput adaptive microscopy approach with machine learning, to identify key biological and physical mechanisms that determine distinct microscopic and macroscopic collective behavior phases which develop as; Bacillus subtilis; swarms expand over five orders of magnitude in space. Our experiments, continuum modeling, and particle-based simulations reveal that macroscopic swarm expansion is primarily driven by cellular growth kinetics, whereas the microscopic swarming motility phases are dominated by physical cell-cell interactions. These results provide a unified understanding of bacterial multiscale behavioral complexity in swarms.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology > Microbiology and Biophysics (Drescher)
UniBasel Contributors:Drescher, Knut
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:National Academy of Sciences
Note:Publication type according to Uni Basel Research Database: Journal article
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edoc DOI:
Last Modified:23 Jun 2021 11:45
Deposited On:23 Jun 2021 11:45

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