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Metabolic View on Human Healthspan: A Lipidome-Wide Association Study

Carrard, Justin and Gallart-Ayala, Hector and Infanger, Denis and Teav, Tony and Wagner, Jonathan and Knaier, Raphael and Colledge, Flora and Streese, Lukas and Königstein, Karsten and Hinrichs, Timo and Hanssen, Henner and Ivanisevic, Julijana and Schmidt-Trucksäss, Arno. (2021) Metabolic View on Human Healthspan: A Lipidome-Wide Association Study. Metabolites, 11 (5). p. 287.

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Official URL: https://edoc.unibas.ch/83498/

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Abstract

As ageing is a major risk factor for the development of non-communicable diseases, extending healthspan has become a medical and societal necessity. Precise lipid phenotyping that captures metabolic individuality could support healthspan extension strategies. This study applied 'omic-scale lipid profiling to characterise sex-specific age-related differences in the serum lipidome composition of healthy humans. A subset of the COmPLETE-Health study, composed of 73 young (25.2 ± 2.6 years, 43% female) and 77 aged (73.5 ± 2.3 years, 48% female) clinically healthy individuals, was investigated, using an untargeted liquid chromatography high-resolution mass spectrometry approach. Compared to their younger counterparts, aged females and males exhibited significant higher levels in 138 and 107 lipid species representing 15 and 13 distinct subclasses, respectively. Percentage of difference ranged from 5.8% to 61.7% (females) and from 5.3% to 46.0% (males), with sphingolipid and glycerophophospholipid species displaying the greatest amplitudes. Remarkably, specific sphingolipid and glycerophospholipid species, previously described as cardiometabolically favourable, were found elevated in aged individuals. Furthermore, specific ether-glycerophospholipid and lyso-glycerophosphocholine species displayed higher levels in aged females only, revealing a more favourable lipidome evolution in females. Altogether, age determined the circulating lipidome composition, while lipid species analysis revealed additional findings that were not observed at the subclass level.
Faculties and Departments:03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sport- und Bewegungsmedizin > Sportmedizin (Schmidt-Trucksäss)
UniBasel Contributors:Hinrichs, Timo and Carrard, Justin and Infanger, Denis and Wagner, Jonathan and Streese, Lukas and Königstein, Karsten and Schmidt-Trucksäss, Arno and Hanssen, Henner
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:MDPI
e-ISSN:2218-1989
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:31 Aug 2021 10:59
Deposited On:31 Aug 2021 10:59

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