Borsari, Chiara and Keles, Erhan and Treyer, Andrea and De Pascale, Martina and Hebeisen, Paul and Hamburger, Matthias and Wymann, Matthias P.. (2021) Second-generation tricyclic pyrimido-pyrrolo-oxazine mTOR inhibitor with predicted blood-brain barrier permeability. RSC Medicinal Chemistry, 12 (4). pp. 579-583.
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Abstract
Highly selective mTOR inhibitors have been discovered through the exploration of the heteroaromatic ring engaging the binding affinity region in mTOR kinase. Compound 11 showed predicted BBB permeability in a MDCK-MDR1 permeability in vitro assay, being the first pyrimido-pyrrolo-oxazine with potential application in the treatment of neurological disorders.
| Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin |
|---|---|
| UniBasel Contributors: | Borsari, Chiara and Keles, Erhan and De Pascale, Martina and Hebeisen, Paul and Treyer, Andrea and Hamburger, Matthias and Wymann, Matthias P. |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| e-ISSN: | 2632-8682 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 18 Jun 2021 07:52 |
| Deposited On: | 18 Jun 2021 07:52 |
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