Multimodal prognosis of negative symptom severity in individuals at increased risk of developing psychosis

Hauke, Daniel J. and Schmidt, André and Studerus, Erich and Andreou, Christina and Riecher-Rössler, Anita and Radua, Joaquim and Kambeitz, Joseph and Ruef, Anne and Dwyer, Dominic B. and Kambeitz-Ilankovic, Lana and Lichtenstein, Theresa and Sanfelici, Rachele and Penzel, Nora and Haas, Shalaila S. and Antonucci, Linda A. and Lalousis, Paris Alexandros and Chisholm, Katharine and Schultze-Lutter, Frauke and Ruhrmann, Stephan and Hietala, Jarmo and Brambilla, Paolo and Koutsouleris, Nikolaos and Meisenzahl, Eva and Pantelis, Christos and Rosen, Marlene and Salokangas, Raimo K. R. and Upthegrove, Rachel and Wood, Stephen J. and Borgwardt, Stefan and the Pronia Group, . (2021) Multimodal prognosis of negative symptom severity in individuals at increased risk of developing psychosis. Translational Psychiatry, 11 (1). p. 312.

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Official URL: https://edoc.unibas.ch/83487/

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Negative symptoms occur frequently in individuals at clinical high risk (CHR) for psychosis and contribute to functional impairments. The aim of this study was to predict negative symptom severity in CHR after 9 months. Predictive models either included baseline negative symptoms measured with the Structured Interview for Psychosis-Risk Syndromes (SIPS-N), whole-brain gyrification, or both to forecast negative symptoms of at least moderate severity in 94 CHR. We also conducted sequential risk stratification to stratify CHR into different risk groups based on the SIPS-N and gyrification model. Additionally, we assessed the models' ability to predict functional outcomes in CHR and their transdiagnostic generalizability to predict negative symptoms in 96 patients with recent-onset psychosis (ROP) and 97 patients with recent-onset depression (ROD). Baseline SIPS-N and gyrification predicted moderate/severe negative symptoms with significant balanced accuracies of 68 and 62%, while the combined model achieved 73% accuracy. Sequential risk stratification stratified CHR into a high (83%), medium (40-64%), and low (19%) risk group regarding their risk of having moderate/severe negative symptoms at 9 months follow-up. The baseline SIPS-N model was also able to predict social (61%), but not role functioning (59%) at above-chance accuracies, whereas the gyrification model achieved significant accuracies in predicting both social (76%) and role (74%) functioning in CHR. Finally, only the baseline SIPS-N model showed transdiagnostic generalization to ROP (63%). This study delivers a multimodal prognostic model to identify those CHR with a clinically relevant negative symptom severity and functional impairments, potentially requiring further therapeutic consideration.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
07 Faculty of Psychology > Departement Psychologie > Society & Choice > Entwicklungs- und Persönlichkeitspsychologie (Grob)
UniBasel Contributors:Studerus, Erich and Andreou, Christina and Schmidt, André
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:26 Jul 2023 08:29
Deposited On:31 Aug 2021 12:13

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