DNA-tethered polymersome clusters as nanotheranostic platform

Meyer, Claire Elsa and Schoenenberger, Cora-Ann and Liu, Juan and Craciun, Ioana and Palivan, Cornelia Gabriela. (2021) DNA-tethered polymersome clusters as nanotheranostic platform. Chimia, 75 (4). pp. 296-299.

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Official URL: https://edoc.unibas.ch/83093/

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Nanotheranostics combine the use of nanomaterials and biologically active compounds to achieve diagnosis and treatment at the same time. To date, severe limitations compromise the use of nanotheranostic systems as potent nanomaterials are often incompatible with potent biomolecules. Herein we emphasize how a novel type of polymersome clusters loaded with active molecules can be optimized to obtain an efficient nanotheranostic platform. Polymersomes loaded with enzymes and specific dyes, respectively and exposing complementary DNA strands at their external surface formed clusters by means of DNA hybridization. We describe factors at the molecular level and other conditions that need to be optimized at each step of the cluster formation to favor theranostic efficiency.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Chemie > Physikalische Chemie (Palivan)
UniBasel Contributors:Meyer, Claire and Schönenberger, Cora-Ann and Palivan, Cornelia G and Liu, Juan and Craciun, Ioana
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Schweizerische Chemische Gesellschaft
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:25 Dec 2021 04:10
Deposited On:25 May 2021 07:45

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