Scaling laws in the functional content of genomes

van Nimwegen, Erik. (2003) Scaling laws in the functional content of genomes. Trends in Genetics, 19 (9). pp. 479-484.

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Official URL: https://edoc.unibas.ch/83038/

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With the number of sequenced genomes now totaling more than 100, and the availability of rough functional annotations for a substantial proportion of their genes, it has become possible to study the statistics of gene content across genomes. In this article I show that, for many high-level functional categories, the number of genes in each category scales as a power-law of the total number of genes in the genome. The occurrence of such scaling laws can be explained using a simple theoretical model, and this model suggests that the exponents of the observed scaling laws correspond to universal constants of the evolutionary process. I discuss some consequences of these scaling laws for our understanding of organism design.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (van Nimwegen)
UniBasel Contributors:van Nimwegen, Erik
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:18 May 2021 10:02
Deposited On:18 May 2021 10:02

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