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The metabolic signature of cardiorespiratory fitness: a protocol for a systematic review and meta-analysis

Carrard, Justin and Guerini, Chiara and Appenzeller-Herzog, Christian and Infanger, Denis and Königstein, Karsten and Streese, Lukas and Hinrichs, Timo and Hanssen, Henner and Gallart-Ayala, Hector and Ivanisevic, Julijana and Schmidt-Trucksäss, Arno. (2021) The metabolic signature of cardiorespiratory fitness: a protocol for a systematic review and meta-analysis. BMJ Open Sport & Exercise Medicine, 7 (1). e001008.

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Abstract

Introduction: A low cardiorespiratory fitness (CRF) is a strong and independent predictor of cardiometabolic, cancer and all-cause mortality. To date, the mechanisms linking CRF with reduced mortality remain largely unknown. Metabolomics, which is a powerful metabolic phenotyping technology to unravel molecular mechanisms underlying complex phenotypes, could elucidate how CRF fosters human health. Methods and analysis: This study aims at systematically reviewing and meta-analysing the literature on metabolites of any human tissue sample, which are positively or negatively associated with CRF. Studies reporting estimated CRF will not be considered. No restrictions will be placed on the metabolomics technology used to measure metabolites. PubMed, Web of Science and EMBASE will be searched for relevant articles published until the date of the last search. Two authors will independently screen full texts of selected abstracts. References and citing articles of included articles will be screened for additional relevant publications. Data regarding study population, tissue samples, analytical technique, quality control, data processing, metabolites associated to CRF, cardiopulmonary exercise test protocol and exercise exhaustion criteria will be extracted. Methodological quality will be assessed using a modified version of QUADOMICS. Narrative synthesis as well as tabular/charted presentation of the extracted data will be included. If feasible, meta-analyses will be used to investigate the associations between identified metabolites and CRF. Potential sources of heterogeneity will be explored in meta-regressions. Ethics and dissemination: No ethics approval is required. The results will be published in a peer-reviewed journal and as conference presentation.
Faculties and Departments:03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sport- und Bewegungsmedizin > Sportmedizin (Schmidt-Trucksäss)
10 Zentrale universitäre Einrichtungen > Universitätsbibliothek
UniBasel Contributors:Carrard, Justin and Appenzeller-Herzog, Christian and Guerini, Chiara and Infanger, Denis and Königstein, Karsten and Streese, Lukas and Hinrichs, Timo and Hanssen, Henner and Schmidt-Trucksäss, Arno
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:BMJ
e-ISSN:2055-7647
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:24 Mar 2021 08:21
Deposited On:24 Mar 2021 08:21

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