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Mathematical modelling of transmission dynamics of Opisthorchis viverrini

Bürli, Christine. Mathematical modelling of transmission dynamics of Opisthorchis viverrini. 2021, Doctoral Thesis, University of Basel, Faculty of Science.

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Abstract

The trematode liver fluke, Opisthorchis viverrini, is endemic in Thailand, Lao People's Democratic Republic (Lao PDR) and Cambodia. Its life cycle involves humans, dogs and cats as definitive hosts; and snails and fish as intermediate hosts. Humans get infected through the consumption of raw or undercooked fish. A severe infection of O. viverrini can lead to cholangiocarcinoma, a mostly fatal bile duct cancer. Control activities include treatment of humans and domestic pets, health education on food consumption and improved sanitation. Mathematical modelling can help us to understand this multi-host disease system, identify weak points in the transmission cycle and determine the effectiveness of combinations of interventions to provide rational advice for the planning of control activities.
Analysis and simulation of a series of mathematical models, ranging from deterministic ordinary differential equations models to stochastic individual-based models, calibrated to data from two islands in the Mekong river in Lao PDR, suggest that (i) mass drug administration is necessary for elimination of O. viverrini to be achieved as quickly as possible; (ii) sustainable education campaigns are as important as mass drug administration; and (iii) it is unlikely that cats and dogs are necessary for transmission to persist.
Advisors:Chitnis, Nakul
Committee Members:Anderson, Roy
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Disease Dynamics > Mathematical Epidemiology (Chitnis)
UniBasel Contributors:Chitnis, Nakul
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:14057
Thesis status:Complete
Number of Pages:ix, 119
Language:English
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss140570
edoc DOI:
Last Modified:26 Mar 2021 05:30
Deposited On:25 Mar 2021 08:16

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