The complete genome sequence of the gram-positive bacterium Bacillus subtilis

Kunst, F. and Ogasawara, N. and Moszer, I. and Albertini, A. M. and Alloni, G. and Azevedo, V. and Bertero, M. G. and Bessières, P. and Bolotin, A. and Borchert, S. and Borriss, R. and Boursier, L. and Brans, A. and Braun, M. and Brignell, S. C. and Bron, S. and Brouillet, S. and Bruschi, C. V. and Caldwell, B. and Capuano, V. and Carter, N. M. and Choi, S. K. and Cordani, J. J. and Connerton, I. F. and Cummings, N. J. and Daniel, R. A. and Denziot, F. and Devine, K. M. and Düsterhöft, A. and Ehrlich, S. D. and Emmerson, P. T. and Entian, K. D. and Errington, J. and Fabret, C. and Ferrari, E. and Foulger, D. and Fritz, C. and Fujita, M. and Fujita, Y. and Fuma, S. and Galizzi, A. and Galleron, N. and Ghim, S. Y. and Glaser, P. and Goffeau, A. and Golightly, E. J. and Grandi, G. and Guiseppi, G. and Guy, B. J. and Haga, K. and Haiech, J. and Harwood, C. R. and Hènaut, A. and Hilbert, H. and Holsappel, S. and Hosono, S. and Hullo, M. F. and Itaya, M. and Jones, L. and Joris, B. and Karamata, D. and Kasahara, Y. and Klaerr-Blanchard, M. and Klein, C. and Kobayashi, Y. and Koetter, P. and Koningstein, G. and Krogh, S. and Kumano, M. and Kurita, K. and Lapidus, A. and Lardinois, S. and Lauber, J. and Lazarevic, V. and Lee, S. M. and Levine, A. and Liu, H. and Masuda, S. and Mauël, C. and Médigue, C. and Medina, N. and Mellado, R. P. and Mizuno, M. and Moestl, D. and Nakai, S. and Noback, M. and Noone, D. and O'Reilly, M. and Ogawa, K. and Ogiwara, A. and Oudega, B. and Park, S. H. and Parro, V. and Pohl, T. M. and Portelle, D. and Porwollik, S. and Prescott, A. M. and Presecan, E. and Pujic, P. and Purnelle, B. and Rapoport, G. and Rey, M. and Reynolds, S. and Rieger, M. and Rivolta, C. and Rocha, E. and Roche, B. and Rose, M. and Sadaie, Y. and Sato, T. and Scanlan, E. and Schleich, S. and Schroeter, R. and Scoffone, F. and Sekiguchi, J. and Sekowska, A. and Seror, S. J. and Serror, P. and Shin, B. S. and Soldo, B. and Sorokin, A. and Tacconi, E. and Takagi, T. and Takahashi, H. and Takemaru, K. and Takeuchi, M. and Tamakoshi, A. and Tanaka, T. and Terpstra, P. and Togoni, A. and Tosato, V. and Uchiyama, S. and Vandebol, M. and Vannier, F. and Vassarotti, A. and Viari, A. and Wambutt, R. and Wedler, H. and Weitzenegger, T. and Winters, P. and Wipat, A. and Yamamoto, H. and Yamane, K. and Yasumoto, K. and Yata, K. and Yoshida, K. and Yoshikawa, H. F. and Zumstein, E. and Yoshikawa, H. and Danchin, A.. (1997) The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature, 390 (6657). pp. 249-256.

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Bacillus subtilis is the best-characterized member of the Gram-positive bacteria. Its genome of 4,214,810 base pairs comprises 4,100 protein-coding genes. Of these protein-coding genes, 53% are represented once, while a quarter of the genome corresponds to several gene families that have been greatly expanded by gene duplication, the largest family containing 77 putative ATP-binding transport proteins. In addition, a large proportion of the genetic capacity is devoted to the utilization of a variety of carbon sources, including many plant-derived molecules. The identification of five signal peptidase genes, as well as several genes for components of the secretion apparatus, is important given the capacity of Bacillus strains to secrete large amounts of industrially important enzymes. Many of the genes are involved in the synthesis of secondary metabolites, including antibiotics, that are more typically associated with Streptomyces species. The genome contains at least ten prophages or remnants of prophages, indicating that bacteriophage infection has played an important evolutionary role in horizontal gene transfer, in particular in the propagation of bacterial pathogenesis.
Faculties and Departments:03 Faculty of Medicine
09 Associated Institutions > Institute of Molecular and Clinical Ophthalmology Basel (IOB)
UniBasel Contributors:Rivolta, Carlo
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:17 Mar 2021 10:49
Deposited On:17 Mar 2021 10:49

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