Quality control and conduct of genome-wide association meta-analyses

Winkler, Thomas W. and Day, Felix R. and Croteau-Chonka, Damien C. and Wood, Andrew R. and Locke, Adam E. and Mägi, Reedik and Ferreira, Teresa and Fall, Tove and Graff, Mariaelisa and Justice, Anne E. and Luan, Jian'an and Gustafsson, Stefan and Randall, Joshua C. and Vedantam, Sailaja and Workalemahu, Tsegaselassie and Kilpeläinen, Tuomas O. and Scherag, André and Esko, Tonu and Kutalik, Zoltán and Heid, Iris M. and Loos, Ruth J. F. and Genetic Investigation of Anthropometric Traits Consortium, . (2014) Quality control and conduct of genome-wide association meta-analyses. Nature Protocols, 9 (5). pp. 1192-1212.

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Official URL: https://edoc.unibas.ch/81758/

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Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational aspects of GWAMAs, and for (ii) QC at the study file level, the meta-level across studies and the meta-analysis output level. Real-world examples highlight issues experienced and solutions developed by the GIANT Consortium that has conducted meta-analyses including data from 125 studies comprising more than 330,000 individuals. We provide a general protocol for conducting GWAMAs and carrying out QC to minimize errors and to guarantee maximum use of the data. We also include details for the use of a powerful and flexible software package called EasyQC. Precise timings will be greatly influenced by consortium size. For consortia of comparable size to the GIANT Consortium, this protocol takes a minimum of about 10 months to complete.
Faculties and Departments:03 Faculty of Medicine
09 Associated Institutions > Institute of Molecular and Clinical Ophthalmology Basel (IOB)
09 Associated Institutions > Institute of Molecular and Clinical Ophthalmology Basel (IOB) > Research Group Rivolta IOB
UniBasel Contributors:Rivolta, Carlo
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 May 2021 11:53
Deposited On:12 May 2021 11:53

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