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Vitamin D moderates the interaction between 5-HTTLPR and childhood abuse in depressive disorders

Bonk, Sarah and Hertel, Johannes and Zacharias, Helena U. and Terock, Jan and Janowitz, Deborah and Homuth, Georg and Nauck, Matthias and Völzke, Henry and Meyer Zu Schwabedissen, Henriette and Van der Auwera, Sandra and Grabe, Hans Jörgen. (2020) Vitamin D moderates the interaction between 5-HTTLPR and childhood abuse in depressive disorders. Scientific reports, 10 (1). p. 22394.

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Official URL: https://edoc.unibas.ch/80799/

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Abstract

A complex interplay between genetic and environmental factors determines the individual risk of depressive disorders. Vitamin D has been shown to stimulate the expression of the tryptophan hydroxylase 2 (TPH2) gene, which is the rate-limiting enzyme for serotonin production in the brain. Therefore, we investigate the hypothesis that serum vitamin D levels moderate the interaction between the serotonin transporter promotor gene polymorphism (5-HTTLPR) and childhood abuse in depressive disorders. Two independent samples from the Study of Health in Pomerania (SHIP-LEGEND: n = 1 997; SHIP-TREND-0: n = 2 939) were used. Depressive disorders were assessed using questionnaires (BDI-II, PHQ-9) and interview procedures (DSM-IV). Besides serum vitamin D levels (25(OH)D), a functional polymorphism (rs4588) of the vitamin D-binding protein is used as a proxy for 25(OH)D. S-allele carriers with childhood abuse and low 25(OH)D levels have a higher mean BDI-II score (13.25) than those with a higher 25(OH)D level (9.56), which was not observed in abused LL-carriers. This significant three-way interaction was replicated in individuals with lifetime major depressive disorders when using the rs4588 instead of 25(OH)D (p = 0.0076 in the combined sample). We conclude that vitamin D relevantly moderates the interaction between childhood abuse and the serotonergic system, thereby impacting vulnerability to depressive disorders.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Biopharmazie (Meyer zu Schwabedissen)
UniBasel Contributors:Meyer zu Schwabedissen, Henriette
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2045-2322
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:28 Feb 2021 20:36
Deposited On:28 Feb 2021 20:36

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