Stress and catecholamines modulate the bone marrow microenvironment to promote tumorigenesis

Hanns, Pauline and Paczulla, Anna M. and Medinger, Michael and Konantz, Martina and Lengerke, Claudia. (2019) Stress and catecholamines modulate the bone marrow microenvironment to promote tumorigenesis. Cell Stress, 3 (7). pp. 221-235.

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Official URL: https://edoc.unibas.ch/80787/

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High vascularization and locally secreted factors make the bone marrow (BM) microenvironment particularly hospitable for tumor cells and bones to a preferred metastatic site for disseminated cancer cells of different origins. Cancer cell homing and proliferation in the BM are amongst other regulated by complex interactions with BM niche cells (e.g. osteoblasts, endothelial cells and mesenchymal stromal cells (MSCs)), resident hematopoietic stem and progenitor cells (HSPCs) and pro-angiogenic cytokines leading to enhanced BM microvessel densities during malignant progression. Stress and catecholamine neurotransmitters released in response to activation of the sympathetic nervous system (SNS) reportedly modulate various BM cells and may thereby influence cancer progression. Here we review the role of catecholamines during tumorigenesis with particular focus on pro-tumorigenic effects mediated by the BM niche.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin
UniBasel Contributors:Konantz, Martina
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Shared Science Publishers
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Jun 2021 13:55
Deposited On:09 Jun 2021 13:55

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