Müller, Andreas Albert. Epidemiologie von Begleitmissbildungen bei Lippen- und Gaumenspalten. 2001, Doctoral Thesis, University of Basel, Faculty of Medicine.
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Abstract
Children with cleft lip and/or cleft palate (CLP) often have additional congenital malformations. The reported incidences are variable and presumed underlying mechanisms are rarely discussed. In this study, 245 CLP patients of a geographically defined population were retrospectively reviewed for additional major malformations and minor anomalies. Malformation incidences in the CLP population were compared to those in a literature-based cohort from the general population. Of the CLP patients, 21% showed either major malformations or minor anomalies. In one-fifth of them a recognized syndrome was identified. Two thirds of the CLP patients with minor anomalies also had major malformations. Major malformations in non-syndromic CLP patients were found with decreasing frequency in the musculoskeletal (5.1%), central nervous (4.2%), urogenital (3.8%) and cardiovascular (3.4%) systems. Malformations in these organ systems and minor anomalies should be ruled out by a specialist. The rise in malformation incidence, when compared to the general population, was highest for organs of ectodermal and ecto-mesodermal origin: central nervous system (13 times), ocular (7 times) and craniofacial system (7 times). The result reflects the close interplay of craniofacial and brain development.
Advisors: | Prein, J. and Hardt, N. |
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Faculties and Departments: | 03 Faculty of Medicine |
Item Type: | Thesis |
Thesis Subtype: | Doctoral Thesis |
Thesis no: | 5590 |
Thesis status: | Complete |
Number of Pages: | 144 |
Language: | German |
Identification Number: |
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edoc DOI: | |
Last Modified: | 13 Jan 2021 15:08 |
Deposited On: | 13 Jan 2021 15:08 |
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