Epidemiologie von Begleitmissbildungen bei Lippen- und Gaumenspalten

Müller, Andreas Albert. Epidemiologie von Begleitmissbildungen bei Lippen- und Gaumenspalten. 2001, Doctoral Thesis, University of Basel, Faculty of Medicine.

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Official URL: https://edoc.unibas.ch/80508/

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Children with cleft lip and/or cleft palate (CLP) often have additional congenital malformations. The reported incidences are variable and presumed underlying mechanisms are rarely discussed. In this study, 245 CLP patients of a geographically defined population were retrospectively reviewed for additional major malformations and minor anomalies. Malformation incidences in the CLP population were compared to those in a literature-based cohort from the general population. Of the CLP patients, 21% showed either major malformations or minor anomalies. In one-fifth of them a recognized syndrome was identified. Two thirds of the CLP patients with minor anomalies also had major malformations. Major malformations in non-syndromic CLP patients were found with decreasing frequency in the musculoskeletal (5.1%), central nervous (4.2%), urogenital (3.8%) and cardiovascular (3.4%) systems. Malformations in these organ systems and minor anomalies should be ruled out by a specialist. The rise in malformation incidence, when compared to the general population, was highest for organs of ectodermal and ecto-mesodermal origin: central nervous system (13 times), ocular (7 times) and craniofacial system (7 times). The result reflects the close interplay of craniofacial and brain development.
Advisors:Prein, J. and Hardt, N.
Faculties and Departments:03 Faculty of Medicine
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:5590
Thesis status:Complete
Number of Pages:144
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss55909
edoc DOI:
Last Modified:13 Jan 2021 15:08
Deposited On:13 Jan 2021 15:08

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