Cryogenic Electron Microscopy enables Drug Research for Membrane Protein Targets

Ni, Dongchun. Cryogenic Electron Microscopy enables Drug Research for Membrane Protein Targets. 2020, Doctoral Thesis, University of Basel, Faculty of Science.


Official URL: https://edoc.unibas.ch/80504/

Downloads: Statistics Overview


This thesis is a collection of my main projects performed over the course of my PhD studies in the past three years. The Results section (Chapters III to V) of this thesis are manuscripts prepared for submission.
Due to global health crises and the growth of pharmaceutical market, drug discovery is in high demand. It is more and more clear that the protein structure determination is an important aspect of the early stages of drug research and development. Furthermore, membrane proteins constitute the majority of druggable targets. Structure determination of membrane proteins is quite challenging with well-established approaches such as NMR and X-ray crystallography. Taking this into account, the goal of my thesis is to apply the new approach of cryogenic electron microscopy single particle analysis in real cases to study membrane proteins as potential drug targets.
Here I have presented three case studies to bring the perspective: How cryo-EM is dealing with the membrane protein and drug researches.
Advisors:Stahlberg, Henning and Perez, Camilo and Ablasser, Andrea
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Stahlberg)
UniBasel Contributors:Stahlberg, Henning and Perez, Camilo
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:13985
Thesis status:Complete
Number of Pages:147
Identification Number:
  • urn: urn:nbn:ch:bel-bau-diss139852
edoc DOI:
Last Modified:06 Jan 2023 02:30
Deposited On:04 Mar 2021 07:36

Repository Staff Only: item control page