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Endogenous cortisol and conditioned placebo effects on pain - A randomized trial

Gaab, Jens and Bürgin, David and Locher, Cosima and Werner, Christoph and Urech, Stefanie and Bratschi, Christine and Garcia, Lorena Bartolomé and Hauke, Milena and Bitter, Salome and Bohny, Marc and Bentz, Dorothée. (2019) Endogenous cortisol and conditioned placebo effects on pain - A randomized trial. Journal of Psychosomatic Research, 123. p. 109739.

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Official URL: https://edoc.unibas.ch/80136/

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Abstract

Placebo effects can be induced by learning and conditioning processes, which in turn are influenced and modulated by glucocorticoids. Accordingly, previous research has shown that intervention-related associative learning can be modulated through exogenous as well as endogenous glucocorticoids. Thus, the aim of this study was to elucidate whether placebo effects induced by conditioning is modulated by daily fluctuations of endogenous cortisol levels in healthy male and female subjects. Overall 77 participants underwent a two-phased placebo conditioning paradigm for pain analgesia. Subjects were randomized in two groups, which underwent placebo preconditioning either in the morning (08:00-10:00, i.e. with high endogenous cortisol levels) or in the afternoon (16:00-18:00, i.e. with low endogenous cortisol levels). Placebo effects were assessed two days later at noontime (12:00-13:00), with possible differences between groups as an indicator of glucocorticoid modulation on the placebo learning. Results indicated a significant conditioned placebo-induced analgesia, resulting in a placebo effect of small to medium size. Cortisol levels on conditioning day significantly differed between groups and cortisol levels were similar during assessment of placebo effects. Groups did not differ in their mean reduction in pain sensation, thus the placebo effect was not affected by differences in cortisol levels during the conditioning of placebo effects. The present study does not indicate a moderation of placebo conditioning by endogenous glucocorticoid levels.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Psychotherapie (Gaab)
UniBasel Contributors:Gaab, Jens and Bentz, Dorothee
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0022-3999
e-ISSN:1879-1360
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:01 Mar 2022 15:47
Deposited On:01 Mar 2022 15:47

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