edoc

The genetic architecture of human brainstem structures and their involvement in common brain disorders

Elvsåshagen, Torbjørn and Bahrami, Shahram and van der Meer, Dennis and Agartz, Ingrid and Alnæs, Dag and Barch, Deanna M. and Baur-Streubel, Ramona and Bertolino, Alessandro and Beyer, Mona K. and Blasi, Giuseppe and Borgwardt, Stefan and Boye, Birgitte and Buitelaar, Jan and Bøen, Erlend and Celius, Elisabeth Gulowsen and Cervenka, Simon and Conzelmann, Annette and Coynel, David and Di Carlo, Pasquale and Djurovic, Srdjan and Eisenacher, Sarah and Espeseth, Thomas and Fatouros-Bergman, Helena and Flyckt, Lena and Franke, Barbara and Frei, Oleksandr and Gelao, Barbara and Harbo, Hanne Flinstad and Hartman, Catharina A. and Håberg, Asta and Heslenfeld, Dirk and Hoekstra, Pieter J. and Høgestøl, Einar A. and Jonassen, Rune and Jönsson, Erik G. and Karolinska Schizophrenia Project consortium, and Kirsch, Peter and Kłoszewska, Iwona and Lagerberg, Trine Vik and Landrø, Nils Inge and Le Hellard, Stephanie and Lesch, Klaus-Peter and Maglanoc, Luigi A. and Malt, Ulrik F. and Mecocci, Patrizia and Melle, Ingrid and Meyer-Lindenberg, Andreas and Moberget, Torgeir and Nordvik, Jan Egil and Nyberg, Lars and Connell, Kevin S. O' and Oosterlaan, Jaap and Papalino, Marco and Papassotiropoulos, Andreas and Pauli, Paul and Pergola, Giulio and Persson, Karin and de Quervain, Dominique and Reif, Andreas and Rokicki, Jaroslav and van Rooij, Daan and Shadrin, Alexey A. and Schmidt, André and Schwarz, Emanuel and Selbæk, Geir and Soininen, Hilkka and Sowa, Piotr and Steen, Vidar M. and Tsolaki, Magda and Vellas, Bruno and Wang, Lei and Westman, Eric and Ziegler, Georg C. and Zink, Mathias and Andreassen, Ole A. and Westlye, Lars T. and Kaufmann, Tobias. (2020) The genetic architecture of human brainstem structures and their involvement in common brain disorders. Nature Communications, 11 (1). p. 4016.

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Official URL: https://edoc.unibas.ch/79804/

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Abstract

Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson's disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Schmidt, André and Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2041-1723
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Jan 2021 09:56
Deposited On:29 Dec 2020 13:43

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