Acute oxytocin effects in inferring others' beliefs and social emotions in people at clinical high risk for psychosis

Schmidt, André and Davies, Cathy and Paloyelis, Yannis and Meyer, Nicholas and De Micheli, Andrea and Ramella-Cravaro, Valentina and Provenzani, Umberto and Aoki, Yuta and Rutigliano, Grazia and Cappucciati, Marco and Oliver, Dominic and Murguia, Silvia and Zelaya, Fernando and Allen, Paul and Shergill, Sukhi and Morrison, Paul and Williams, Steve and Taylor, David and Borgwardt, Stefan and Yamasue, Hidenori and McGuire, Philip and Fusar-Poli, Paolo. (2020) Acute oxytocin effects in inferring others' beliefs and social emotions in people at clinical high risk for psychosis. Translational Psychiatry, 10 (1). p. 203.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/79801/

Downloads: Statistics Overview


Social deficits are key hallmarks of the Clinical High Risk for Psychosis (CHR-P) state and of established psychotic disorders, and contribute to impaired social functioning, indicating a potential target for interventions. However, current treatments do not significantly ameliorate social impairments in CHR-P individuals. Given its critical role in social behaviour and cognition, the oxytocinergic (OT) system is a promising target for novel interventions in CHR-P subjects. In a double-blind, placebo-controlled, crossover design, 30 CHR-P males were studied using functional magnetic resonance imaging (fMRI) on two occasions, once after 40IU self-administered intranasal OT and once after placebo. A modified version of the Sally-Anne task was used to assess brain activation during inferring others' beliefs and social emotions. The Reading the Mind in the Eyes Test was acquired prior to the first scan to test whether OT effects were moderated by baseline social-emotional abilities. OT did not modulate behavioural performances but reduced activation in the bilateral inferior frontal gyrus compared with placebo while inferring others' social emotions. Furthermore, the relationship between brain activation and task performance after OT administration was moderated by baseline social-emotional abilities. While task accuracy during inferring others' social emotion increased with decreasing activation in the left inferior frontal gyrus in CHR-P individuals with low social-emotional abilities, there was no such relationship in CHR-P individuals with high social-emotional abilities. Our findings may suggest that acute OT administration enhances neural efficiency in the inferior frontal gyrus during inferring others' social emotions in those CHR-P subjects with low baseline social-emotional abilities.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
UniBasel Contributors:Schmidt, André
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:29 Dec 2020 13:31
Deposited On:29 Dec 2020 13:31

Repository Staff Only: item control page