edoc

Genetic control of variability in subcortical and intracranial volumes

Córdova-Palomera, Aldo and van der Meer, Dennis and Kaufmann, Tobias and Bettella, Francesco and Wang, Yunpeng and Alnæs, Dag and Doan, Nhat Trung and Agartz, Ingrid and Bertolino, Alessandro and Buitelaar, Jan K. and Coynel, David and Djurovic, Srdjan and Dørum, Erlend S. and Espeseth, Thomas and Fazio, Leonardo and Franke, Barbara and Frei, Oleksandr and Håberg, Asta and Le Hellard, Stephanie and Jönsson, Erik G. and Kolskår, Knut K. and Lund, Martina J. and Moberget, Torgeir and Nordvik, Jan E. and Nyberg, Lars and Papassotiropoulos, Andreas and Pergola, Giulio and de Quervain, Dominique and Rampino, Antonio and Richard, Genevieve and Rokicki, Jaroslav and Sanders, Anne-Marthe and Schwarz, Emanuel and Smeland, Olav B. and Steen, Vidar M. and Starrfelt, Jostein and Sønderby, Ida E. and Ulrichsen, Kristine M. and Andreassen, Ole A. and Westlye, Lars T.. (2020) Genetic control of variability in subcortical and intracranial volumes. Molecular psychiatry.

[img] PDF - Accepted Version
1255Kb

Official URL: https://edoc.unibas.ch/79642/

Downloads: Statistics Overview

Abstract

Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at the cost of increased risk of adverse outcomes when facing poor environmental conditions. Here, we apply a novel methodology to perform genome-wide association analysis of mean and variance in ten key brain features (accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus, intracranial volume, cortical surface area, and cortical thickness), integrating genetic and neuroanatomical data from a large lifespan sample (n = 25,575 individuals; 8-89 years, mean age 51.9 years). We identify genetic loci associated with phenotypic variability in thalamus volume and cortical thickness. The variance-controlling loci involved genes with a documented role in brain and mental health and were not associated with the mean anatomical volumes. This proof-of-principle of the hypothesis of a genetic regulation of brain volume variability contributes to establishing the genetic basis of phenotypic variance (i.e., heritability), allows identifying different degrees of brain robustness across individuals, and opens new research avenues in the search for mechanisms controlling brain and mental health.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Cognitive Neuroscience (de Quervain)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Coynel, David and de Quervain, Dominique J.-F. and Papassotiropoulos, Andreas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Springer Nature
ISSN:1359-4184
e-ISSN:1476-5578
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
edoc DOI:
Last Modified:22 Jan 2021 09:51
Deposited On:14 Dec 2020 16:47

Repository Staff Only: item control page