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Practical management of adverse events in patients with advanced systemic mastocytosis receiving midostaurin

Gotlib, Jason and Kluin-Nelemans, Hanneke C. and Akin, Cem and Hartmann, Karin and Valent, Peter and Reiter, Andreas. (2021) Practical management of adverse events in patients with advanced systemic mastocytosis receiving midostaurin. Expert Opinion on Biological Therapy, 21 (4). pp. 487-498.

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Official URL: https://edoc.unibas.ch/79606/

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Abstract

Systemic mastocytosis (SM) is characterized by the over-production and accumulation of neoplastic mast cells (MCs) in the bone marrow, skin, and visceral organs. The; KIT; D816V mutation is found in approximately 90% of cases. In advanced SM (advSM), inferior survival often relates to MC-induced organ damage that may impact multiple organ systems. In addition, mediator symptoms related to MC activation can severely impact quality of life. The oral multikinase/KIT inhibitor midostaurin was approved by the US Food and Drug Administration and the European Medicines Agency as monotherapy for advSM based on data from phase 2 clinical studies.; This review discusses the management of common adverse events (AEs) in patients with advSM who participated in phase 2 clinical studies that led to the approval of midostaurin.; In the advSM population undergoing treatment with midostaurin, treatment-related AEs are often difficult to distinguish from disease-related symptoms, which can lead to premature discontinuation and improper dose reduction of midostaurin therapy in patients who might have benefitted from continued therapy. Here we present strategies to help optimize AE management and maximize the potential benefits of midostaurin in advSM.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Allergologie (Hartmann)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Allergologie (Hartmann)
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Taylor and Francis
ISSN:1471-2598
e-ISSN:1744-7682
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:18 May 2022 15:44
Deposited On:18 May 2022 15:44

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