Stader, Felix and Decosterd, Laurent and Stoeckle, Marcel and Cavassini, Matthias and Battegay, Manuel and Saldanha, Susana Alves and Marzolini, Catia and Courlet, Perrine and The Swiss HIV Cohort Study, . (2020) Aging does not impact drug--drug interaction magnitudes with antiretrovirals. AIDS, 34 (6). pp. 949-952.
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Official URL: https://edoc.unibas.ch/78791/
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Abstract
: The risk of drug-drug interactions (DDIs) is elevated in aging people living with HIV (PLWH) because of highly prevalent age-related comorbidities leading to more comedications. To investigate the impact of aging on DDI magnitudes between comedications (amlodipine, atorvastatin, rosuvastatin) and boosted darunavir, we conducted a clinical trial in aging PLWH aged at least 55 years. DDI magnitudes were comparable with those reported in young individuals supporting that the clinical management of DDIs in aging PLWH can be similar.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Infektiologie > Infektiologie (Battegay M) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Infektiologie > Infektiologie (Battegay M) |
|---|---|
| UniBasel Contributors: | Marzolini, Catia |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Lippincott, Williams & Wilkins |
| ISSN: | 0269-9370 |
| e-ISSN: | 1473-5571 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 29 Dec 2020 10:55 |
| Deposited On: | 29 Dec 2020 10:55 |
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