Fu, Wenxiang and Hall, Michael N.. (2020) Regulation of mTORC2 Signaling. Genes, 11 (9). p. 1045.
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Abstract
Mammalian target of rapamycin (mTOR), a serine/threonine protein kinase and a master regulator of cell growth and metabolism, forms two structurally and functionally distinct complexes, mTOR complex 1 (mTORC1) and mTORC2. While mTORC1 signaling is well characterized, mTORC2 is relatively poorly understood. mTORC2 appears to exist in functionally distinct pools, but few mTORC2 effectors/substrates have been identified. Here, we review recent advances in our understanding of mTORC2 signaling, with particular emphasis on factors that control mTORC2 activity.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall) |
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UniBasel Contributors: | Hall, Michael N. and Fu, Wenxiang |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | MDPI |
e-ISSN: | 2073-4425 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Identification Number: |
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edoc DOI: | |
Last Modified: | 15 Sep 2020 10:03 |
Deposited On: | 15 Sep 2020 10:03 |
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