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Disfiguring annular sarcoidosis improved by adalimumab

Kaiser, Christoph A. and Cozzio, Antonio and Hofbauer, Günther F. L. and Kamarashev, J. and French, Lars E. and Navarini, Alexander A.. (2011) Disfiguring annular sarcoidosis improved by adalimumab. Case Reports in Dermatology, 3 (2). pp. 103-106.

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Official URL: https://edoc.unibas.ch/78103/

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Abstract

Depending on the location, dermatoses can produce blemishes that severely impair quality of life and require highly effective treatment that is otherwise used for extensive skin involvement. We report the case of a 39-year-old, otherwise healthy male disfigured by an 8 × 7-cm hypopigmented and centrally atrophic annular plaque with erythematous indurated borders in an area of scar tissue on his forehead. Skin biopsies revealed non-caseating granulomas, and hilar involvement was identified, leading to the diagnosis of systemic sarcoidosis stage II with cutaneous involvement. The lesions proved resistant to multiple therapies, but responded within 4 months to adalimumab with regression of the lesion and inflammatory infiltrate. The visual analogue scale of disease activity decreased from 7/10 to 3.5/10, and the Dermatology Life Quality Index from 16/30 to 3/30 points. In conclusion, TNF-α inhibition can control inflammation and disfigurement by cutaneous sarcoidosis and restore quality of life.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:Karger
e-ISSN:1662-6567
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:30 Sep 2020 12:28
Deposited On:30 Sep 2020 09:31

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