Outdoor Temperature Influences Cold Induced Thermogenesis in Humans

Senn, Jaël R. and Maushart, Claudia I. and Gashi, Gani and Michel, Regina and Lalive d'Epinay, Murielle and Vogt, Roland and Becker, Anton S. and Müller, Julian and Baláz, Miroslav and Wolfrum, Christian and Burger, Irene A. and Betz, Matthias J.. (2018) Outdoor Temperature Influences Cold Induced Thermogenesis in Humans. Frontiers in physiology, 9. p. 1184.

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Official URL: https://edoc.unibas.ch/77953/

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Objective: Energy expenditure (EE) increases in response to cold exposure, which is called cold induced thermogenesis (CIT). Brown adipose tissue (BAT) has been shown to contribute significantly to CIT in human adults. BAT activity and CIT are acutely influenced by ambient temperature. In the present study, we investigated the long-term effect of seasonal temperature variation on human CIT.Materials and Methods: We measured CIT in 56 healthy volunteers by indirect calorimetry. CIT was determined as difference between EE during warm conditions (EE warm ) and after a defined cold stimulus (EE cold ). We recorded skin temperatures at eleven anatomically predefined locations, including the supraclavicular region, which is adjacent to the main human BAT depot. We analyzed the relation of EE, CIT and skin temperatures to the daily minimum, maximum and mean outdoor temperature averaged over 7 or 30 days, respectively, prior to the corresponding study visit by linear regression.Results: We observed a significant inverse correlation between outdoor temperatures and EE cold and CIT, respectively, while EE warm was not influenced. The daily maximum temperature averaged over 7 days correlated best with EE cold (R 2 = 0.123, p = 0.008) and CIT (R 2 = 0.200, p = 0.0005). The mean skin temperatures before and after cold exposure were not related to outdoor temperatures. However, the difference between supraclavicular and parasternal skin temperature after cold exposure was inversely related to the average maximum temperature during the preceding 7 days (R 2 = 0.07575, p = 0.0221).Conclusion: CIT is significantly related to outdoor temperatures indicating dynamic adaption of thermogenesis and BAT activity to environmental stimuli in adult humans.Clinical Trial Registration:www.ClinicalTrials.gov
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Ehemalige Einheiten Umweltwissenschaften > Meteorologie (Parlow)
UniBasel Contributors:Vogt, Roland and Betz, Matthias Johannes Maximilian
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Media
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Oct 2023 14:49
Deposited On:21 Aug 2020 13:25

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