edoc

A quantitative risk assessment for skin sensitizing plant protection products: Linking derived No-Effect levels (DNELs) with agricultural exposure models

Sanvido, Olivier and Schmid, Kaspar and FitzGerald, Rex E. and Roth, Nicolas and Wilks, Martin F. and Bormann, Peter and Hopf, Nancy B.. (2018) A quantitative risk assessment for skin sensitizing plant protection products: Linking derived No-Effect levels (DNELs) with agricultural exposure models. Regulatory toxicology and pharmacology, 98. pp. 171-183.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/77932/

Downloads: Statistics Overview

Abstract

Chemical skin sensitizers produce allergic contact dermatitis, which is one of the most frequent occupational diseases associated with chemical exposures. Skin exposure is the major route of exposure when using plant protection products (PPPs). Therefore, skin sensitization is an important factor to be addressed during the regulatory risk assessment of PPPs. The main regulatory decision criterion considered when performing risk assessment for skin sensitizers is the dose applied. The equally important criteria "potency of the substance" is insufficiently considered by two potency categories as potency may vary up to five orders of magnitude. "Frequency of exposure" to the skin sensitizer is not considered at all. Consequently, an improved risk assessment methodology is essential to adequately assess health risks from skin sensitizers, especially for agricultural operators using PPPs. A quantitative risk assessment (QRA) approach for addressing PPPs sensitizing potential is proposed here. This QRA combines a methodology to derive a substance-specific threshold for skin sensitizers, a Derived No-Effect Level (DNEL), and an agricultural exposure model used for assessing chronic health risks of PPPs. The proposed QRA for skin sensitizing PPPs is a clear improvement over current risk assessment to ensure the safe use of skin sensitizers in an occupational context.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften
05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Regulatory Toxicology (Wilks)
UniBasel Contributors:FitzGerald, Reginald Edward and Wilks, Martin F. and Roth, Nicolas
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:1096-0295
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:18 Sep 2020 03:10
Deposited On:21 Aug 2020 13:02

Repository Staff Only: item control page