Sarcevic, Jelena and Cavelti-Weder, Claudia and Berger, T. Christoph and Trendelenburg, Marten. (2020) Secondary Antibody Deficiency Due to Endogenous Hypercortisolism. Frontiers in Immunology, 11. p. 1435.
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Official URL: https://edoc.unibas.ch/77772/
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Abstract
Therapeutic corticosteroids have an immunosuppressive function involving several pathways, including lymphocytopenia and hypogammaglobulinemia. While these effects have been well-described in patients that received corticosteroids for therapeutic reasons, the effects of endogenous corticosteroids on the immune system are less well-understood. Here, we describe a 21-year old patient with hypercortisolism due to an ACTH producing thymic tumor. In this patient, we observed a decrease in some of the immunoglobulin classes, and in specific B and T cell populations that resembled effects caused by corticosteroid treatment. IgG levels were restored following treatment and normalization of the hypercortisolism.
Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin USB > Innere Medizin (Bassetti) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Allgemeine innere Medizin USB > Innere Medizin (Bassetti) |
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UniBasel Contributors: | Sarcevic, Jelena and Cavelti-Weder, Claudia and Berger, Christoph T. and Trendelenburg, Marten |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Frontiers Media |
e-ISSN: | 1664-3224 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Related URLs: | |
Identification Number: |
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Last Modified: | 29 Dec 2020 08:25 |
Deposited On: | 29 Dec 2020 08:25 |
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