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Safety profile of the meningococcal conjugate vaccine (Menafrivactm) in clinical trials and vaccination campaigns: a review of published studies

Ateudjieu, Jerome and Stoll, Beat and Bisseck, Anne Cecile and Tembei, Ayok M. and Genton, Blaise. (2020) Safety profile of the meningococcal conjugate vaccine (Menafrivactm) in clinical trials and vaccination campaigns: a review of published studies. Human vaccines & immunotherapeutics, 16 (6). pp. 1245-1259.

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Official URL: https://edoc.unibas.ch/77730/

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Abstract

The study aimed to assess the capacity of AEFI surveillance during vaccination campaigns with the new conjugate meningitis vaccine (MenAfrivac). A systematic review of studies on MenAfrivactm published in English during 2001-2016 was done.AEFIs incidence (I) was estimated and compared between MenAfrivactm clinical trials and immunization campaigns using incidence difference (Id). Nine studies were included with an overall local AEFI I of 11,496/100,000 doses administered per week in clinical trials and 0.72/100,000 doses in immunization campaigns. An Id of 11,497.92 [11,497.91-11,497.93] and 17,243.20 [17,241.80-17,245.90] per 100,000 doses administered per week for overall local and systemic AEFI, respectively, were observed with highest from clinical trials. The incidence of AEFIs after MenAfrivactm vaccination was far lower in campaigns than in clinical trial studies. Current capacity of AEFI surveillance during vaccination campaigns requires extensive re-assessment of its structure and capacity.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Clinical Epidemiology (Genton)
UniBasel Contributors:Genton, Blaise
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Landes Bioscience
ISSN:2164-554X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:10 Jul 2020 12:44
Deposited On:10 Jul 2020 12:44

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