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Low serum DHEA-S is associated with impaired lung function in women

Pesce, Giancarlo and Triebner, Kai and van der Plaat, Diana A. and Courbon, Dominique and Hustad, Steinar and Sigsgaard, Torben and Nowak, Dennis and Heinrich, Joachim and Anto, Josep M. and Dorado-Arenas, Sandra and Martinez-Moratalla, Jesús and Gullon-Blanco, Jose A. and Sanchez-Ramos, José L. and Raherison, Chantal and Pin, Isabelle and Demoly, Pascal and Gislason, Thorarinn and Torén, Kjell and Forsberg, Bertil and Lindberg, Eva and Zemp, Elisabeth and Jogi, Rain and Probst-Hensch, Nicole and Dharmage, Shyamali C. and Jarvis, Debbie and Garcia-Aymerich, Judith and Marcon, Alessandro and Gómez-Real, Francisco and Leynaert, Bénédicte. (2020) Low serum DHEA-S is associated with impaired lung function in women. EClinicalMedicine, 23. p. 100389.

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Official URL: https://edoc.unibas.ch/77469/

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Abstract

Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS).; Lung function and serum DHEA-S concentrations were measured in; n; = 2,045 and; n; = 1,725 women in 1999-2002 and in 2010-2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999-2002 with incidence of restrictive pattern and airflow limitation in 2010-2013 were also assessed.; Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14).; Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health.; EU H2020, grant agreement no.633212.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Society, Gender and Health > Gender and Health (Zemp Stutz)
UniBasel Contributors:Zemp Stutz, Elisabeth and Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:2589-5370
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:17 Jun 2020 11:06
Deposited On:17 Jun 2020 11:06

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