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Locomotion replacement exercise cannot counteract cartilage biomarker response to 5 days of immobilization in healthy adults

Liphardt, Anna-Maria and Mündermann, Annegret and Heer, Martina and Achtzehn, Silvia and Niehoff, Anja and Mester, Joachim. (2020) Locomotion replacement exercise cannot counteract cartilage biomarker response to 5 days of immobilization in healthy adults. Journal of Orthopaedic Research.

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Abstract

Biomarkers of cartilage metabolism are sensitive to changes in the biological and mechanical environment and can indicate early changes in cartilage homeostasis. The purpose of this study was to determine if a daily locomotion replacement program can serve as a countermeasure for changes in cartilage biomarker serum concentration caused by immobilization. Ten healthy male subjects (mean ± 1 standard deviation, age: 29.4±5.9 years; body mass: 77.7±4.1 kg) participated in the cross-over 5 days bed rest study with three interventions: control (CON), standing (STA) and locomotion replacement training (LRT). Serum samples were taken before, during, and after bed rest. Biomarker concentrations were measured using commercial enzyme-linked immunosorbent assays. Cartilage oligomeric matrix protein (COMP) levels after 24hrs of bed rest decreased independently of the intervention (-16.8 to -9.8%) and continued to decreased until 72hrs of bed rest (minimum, -23.2 to -20.6%). LRT and STA did not affect COMP during bed rests (p=0.056) but there was a strong tendency for a slower decrease with LRT (-9.4%) and STA (-11.7%) compared to CON (-16.8%). MMP-3 levels decreased within the first 24hrs of bed rest (CON: -22.3%; STA: -14.7%; LRT: -17%) without intervention effect. Both COMP and MMP-3 levels recovered to baseline levels during the 6 days recovery period. MMP-1, MMP-9 and TNF-alpha levels were not affected by immobilization or intervention. COMP and MMP-3 are mechanosensitive cartilage biomarkers affected by immobilization, and simple interventions such as standing upright or LRT during bed rest cannot prevent these changes. Clinical significance: Simple locomotion interventions cannot prevent cartilage biomarker change during bed rest.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedical Engineering > Biomechanics and Biomaterials
03 Faculty of Medicine > Departement Klinische Forschung
03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Bewegungsapparat und Integument > Traumatologie / Orthopädie (Jakob)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Bewegungsapparat und Integument > Traumatologie / Orthopädie (Jakob)
UniBasel Contributors:Mündermann, Annegret
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0736-0266
e-ISSN:1554-527X
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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edoc DOI:
Last Modified:24 Jul 2020 03:10
Deposited On:09 Jun 2020 06:37

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