Spitzoid melanoma and micrometastases in two lymph node regions: a critical situation

Navarini, Alexander A. and Bauer, Jürgen and Barysch, Marjam J. and Kempf, Werner and Mihic-Probst, Daniela and Kerl, Katrin and Kamarashev, Jivko and Giovanoli, Pietro and Kolios, Antonios G. A. and Bergstraesser, Eva and Dummer, Reinhard. (2011) Spitzoid melanoma and micrometastases in two lymph node regions: a critical situation. European journal of dermatology : EJD, 21 (2). pp. 229-233.

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Official URL: https://edoc.unibas.ch/76804/

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Atypical Spitz tumors can hardly be differentiated from spitzoid melanoma. CGH might help in the differential diagnosis. An 8 year old child with an atypical Spitz tumor (with a CGH pattern compatible with melanoma) of 8.0 mm Breslow thickness and micrometastases in two lymph node regions was seen at our department. The management and prognosis of atypical Spitz tumors is controversial, and aggressive procedural steps similar to melanoma are usually not recommended. Even performing sentinel lymph node biopsy has been questioned. After extensive interdisciplinary consultations, we did not recommend resection of both lymph node regions and chose instead to follow-up with regular whole-body MRI and adjuvant treatment with pegylated interferon. Treatment decisions for atypical Spitz tumors are a major medical and ethical challenge due to the limited available data.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:John Libbey Eurotext
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Sep 2020 09:59
Deposited On:30 Sep 2020 09:59

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