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MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus

Lang, Karl S. and Navarini, Alexander A. and Recher, Mike and Lang, Philipp A. and Heikenwalder, Mathias and Stecher, Barbara and Bergthaler, Andreas and Odermatt, Bernhard and Akira, Shizuo and Honda, Kenya and Hengartner, Hans and Zinkernagel, Rolf M.. (2007) MyD88 protects from lethal encephalitis during infection with vesicular stomatitis virus. European Journal of Immunology, 37 (9). pp. 2434-2440.

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Official URL: https://edoc.unibas.ch/76689/

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Abstract

MyD88 is a key adaptor molecule in innate resistance, engaged in most Toll-like receptor, as well as IL-1 and IL-18, signalling. Here, we analyzed the role of MyD88 in innate resistance during infection with vesicular stomatitis virus (VSV) using myd88(-/-) mice. We found an increased susceptibility to VSV in myd88(-/-) mice, which was not explained by reduced type I IFN or neutralizing antibody responses. Susceptibility of myd88(-/-) mice correlated with impaired recruitment of immune cells to the site of infection. In the absence of MyD88 signalling, VSV rapidly spread to the spinal cord and brain causing lethal encephalitis.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Wiley
ISSN:0014-2980
e-ISSN:1521-4141
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Sep 2020 10:59
Deposited On:30 Sep 2020 10:59

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