The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis

Lande, Roberto and Botti, Elisabetta and Jandus, Camilla and Dojcinovic, Danijel and Fanelli, Giorgia and Conrad, Curdin and Chamilos, Georgios and Feldmeyer, Laurence and Marinari, Barbara and Chon, Susan and Vence, Luis and Riccieri, Valeria and Guillaume, Phillippe and Navarini, Alex A. and Romero, Pedro and Costanzo, Antonio and Piccolella, Enza and Gilliet, Michel and Frasca, Loredana. (2014) The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis. Nature communications, 5. p. 5621.

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Official URL: https://edoc.unibas.ch/76681/

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Psoriasis is a common T-cell-mediated skin disease with 2-3% prevalence worldwide. Psoriasis is considered to be an autoimmune disease, but the precise nature of the autoantigens triggering T-cell activation remains poorly understood. Here we find that two-thirds of patients with moderate-to-severe plaque psoriasis harbour CD4(+) and/or CD8(+) T cells specific for LL37, an antimicrobial peptide (AMP) overexpressed in psoriatic skin and reported to trigger activation of innate immune cells. LL37-specific T cells produce IFN-γ, and CD4(+) T cells also produce Th17 cytokines. LL37-specific T cells can infiltrate lesional skin and may be tracked in patients blood by tetramers staining. Presence of circulating LL37-specific T cells correlates significantly with disease activity, suggesting a contribution to disease pathogenesis. Thus, we uncover a role of LL37 as a T-cell autoantigen in psoriasis and provide evidence for a role of AMPs in both innate and adaptive immune cell activation.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:02 Jun 2020 08:34
Deposited On:02 Jun 2020 08:34

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