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Detection of Small Changes in Psoriasis Intensity with PrecisePASI

Kolios, Antonios G. A. and French, Lars E. and Navarini, Alexander A.. (2015) Detection of Small Changes in Psoriasis Intensity with PrecisePASI. Dermatology (Basel, Switzerland), 230 (4). pp. 314-317.

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Official URL: https://edoc.unibas.ch/76678/

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Abstract

The Psoriasis Area and Severity Index (PASI) is the score of choice to grade psoriasis severity and detect clinical changes. Due to low resolution based on the calculation of the score by fixed area classes, PASI scores <10 have little value.; At 756 patient examinations, psoriasis activity was measured with both PASI and PrecisePASI.; PrecisePASI has a linear increase while PASI has a staircase pattern. Both scores meet at the endpoint-relevant values of body surface area (BSA) 10, 30, 50, 70 and 90%. PASI and PrecisePASI correlate significantly over the whole range of BSA. In the region of BSA <5%, PrecisePASI shows a significantly higher resolution (p < 0.0001).; The calculation of PrecisePASI corrects the undesired inaccuracies of PASI in the lower BSA ranges and is a tool to use as an endpoint in trials aiming to detect differences in the lower ranges of BSA.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialf├Ącher (Klinik) > Dermatologie USB > Dermatologie (Navarini)
UniBasel Contributors:Navarini, Alexander
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1421-9832
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:22 May 2020 16:18
Deposited On:22 May 2020 16:18

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