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The association between ambient NO2 and PM2.5 with the respiratory health of school children residing in informal settlements: a prospective cohort study

Olaniyan, Toyib and Jeebhay, Mohamed and Röösli, Martin and Naidoo, Rajen N. and Künzli, Nino and de Hoogh, Kees and Saucy, Apolline and Badpa, Mahnaz and Baatjies, Roslynn and Parker, Bhawoodien and Leaner, Joy and Dalvie, Mohamed Aqiel. (2020) The association between ambient NO2 and PM2.5 with the respiratory health of school children residing in informal settlements: a prospective cohort study. Environmental research, 186. p. 109606.

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Official URL: https://edoc.unibas.ch/76577/

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Abstract

No previous epidemiological study has investigated the combined association of long-term ambient nitrogen dioxide (NO; 2; ) and particulate matter of diameter size-2.5 (PM; 2.5; ) exposure with asthma outcomes among schoolchildren in Africa.; This study investigated the independent and co-pollutant association of long-term exposures to ambient air pollutants on asthma-associated outcomes in a cohort of schoolchildren in the Western Cape Province of South Africa.; A total of 590 grade-4 schoolchildren residing in four informal settlements were studied. Spirometry and fractional exhaled nitric-oxide (FeNO) measurements were conducted, including a standardized questionnaire administered to caregivers at baseline and 12-months follow-up. Annual NO; 2; and PM; 2.5; levels were estimated for each child's home using land-use regression modelling. Single- and two-pollutant models were constructed to assess the independent and co-pollutant association of both air pollutants (NO; 2; and PM; 2.5; ) on new cases of asthma-associated outcomes adjusting-for host characteristics, indoor exposures and study area.; The annual average concentration of PM; 2.5; and NO; 2; were 10.01μg/m; 3; and 16.62μg/m; 3; respectively, across the four study areas, and were below the local Standards of 20μg/m; 3; and 40μg/m; 3; , for both pollutants, respectively. In the two-pollutant-adjusted models, an interquartile range (IQR) increase of 14.2μg/m; 3; in NO; 2; was associated with an increased risk of new onset of ocular-nasal symptoms (adjusted odds ratio-aOR: 1.63, 95% CI: 1.01-2.60), wheezing (aOR: 3.57, 95% CI: 1.18-10.92), more than two or more asthma symptom score (aOR: 1.71, 95% CI: 1.02-2.86), and airway inflammation defined as FeNO > 35 ppb (aOR: 3.10, 95% CI: 1.10-8.71), independent of PM; 2.5; exposures.; This study provided evidence that ambient NO; 2; levels below local standards and international guidelines, independent of PM; 2.5; exposure, increases new cases of asthma-associated outcomes after 12-months.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health > Physical Hazards and Health (Röösli)
UniBasel Contributors:Röösli, Martin and Künzli, Nino and de Hoogh, Kees and Saucy, Apolline and Badpa, Mahnaz
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0013-9351
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:13 May 2020 14:41
Deposited On:13 May 2020 14:41

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