Recombinant LCMV Vectors Induce Protective Immunity following Homologous and Heterologous Vaccinations

Wingerath, Jessica and Ostroumov, Dmitrij and Woller, Norman and Manns, Michael P. and Pinschewer, Daniel D. and Orlinger, Klaus and Berka, Ursula and Kühnel, Florian and Wirth, Thomas C.. (2017) Recombinant LCMV Vectors Induce Protective Immunity following Homologous and Heterologous Vaccinations. Molecular Therapy, 25 (11). pp. 2533-2545.

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Official URL: https://edoc.unibas.ch/76562/

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Successful vaccination against cancer and infectious diseases relies on the induction of adaptive immune responses that induce high-titer antibodies or potent cytoxic T cell responses. In contrast to humoral vaccines, the amplification of cellular immune responses is often hampered by anti-vector immunity that either pre-exists or develops after repeated homologous vaccination. Replication-defective lymphocytic choriomeningitis virus (LCMV) vectors represent a novel generation of vaccination vectors that induce potent immune responses while escaping recognition by neutralizing antibodies. Here, we characterize the CD8 T cell immune response induced by replication-defective recombinant LCMV (rLCMV) vectors with regard to expansion kinetics, trafficking, phenotype, and function and we perform head-to-head comparisons of the novel rLCMV vectors with established vectors derived from adenovirus, vaccinia virus, or Listeria monocytogenes. Our results demonstrate that replication-deficient rLCMV vectors are safe and ideally suited for both homologous and heterologous vaccination regimens to achieve optimal amplification of CD8 T cell immune responses in vivo.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Experimental Virology (Pinschewer)
UniBasel Contributors:Pinschewer, Daniel
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:20 Aug 2020 14:56
Deposited On:20 Aug 2020 14:56

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