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microRNA expression profiles and personal monitoring of exposure to particulate matter

Mancini, Francesca Romana and Laine, Jessica E. and Tarallo, Sonia and Vlaanderen, Jelle and Vermeulen, Roel and van Nunen, Erik and Hoek, Gerard and Probst-Hensch, Nicole and Imboden, Medea and Jeong, Ayoung and Gulliver, John and Chadeau-Hyam, Marc and Nieuwenhuijsen, Mark and de Kok, Theo M. and Piepers, Jolanda and Krauskopf, Julian and Kleinjans, Jos C. S. and Vineis, Paolo and Naccarati, Alessio. (2020) microRNA expression profiles and personal monitoring of exposure to particulate matter. Environmental Pollution, 263 (Pt B). p. 114392.

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Official URL: https://edoc.unibas.ch/76314/

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Abstract

An increasing number of findings from epidemiological studies support associations between exposure to air pollution and the onset of several diseases, including pulmonary, cardiovascular and neurodegenerative diseases, and malignancies. However, intermediate, and potentially mediating, biological mechanisms associated with exposure to air pollutants are largely unknown. Previous studies on the human exposome have shown that the expression of certain circulating microRNAs (miRNAs), regulators of gene expression, are altered upon exposure to traffic-related air pollutants. In the present study, we investigated the relationship between particulate matter (PM) smaller than 2.5 μm (PM; 2.5; ), PM; 2.5; absorbance (as a proxy of black carbon and soot), and ultrafine-particles (UFP, smaller than 0.1 μm), measured in healthy volunteers by 24 h personal monitoring (PEM) sessions and global expression levels of peripheral blood miRNAs. The PEM sessions were conducted in four European countries, namely Switzerland (Basel), United Kingdom (Norwich), Italy (Turin), and The Netherlands (Utrecht). miRNAs expression levels were analysed using microarray technology on blood samples from 143 participants. Seven miRNAs, hsa-miR-24-3p, hsa-miR-4454, hsa-miR-4763-3p, hsa-miR-425-5p, hsa-let-7d-5p, hsa-miR-502-5p, and hsa-miR-505-3p were significantly (FDR corrected) expressed in association with PM; 2.5; personal exposure, while no significant association was found between miRNA expression and the other pollutants. The results obtained from this investigation suggest that personal exposure to PM; 2.5; is associated with miRNA expression levels, showing the potential for these circulating miRNAs as novel biomarkers for air pollution health risk assessment.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Probst Hensch, Nicole and Imboden, Medea and Jeong, Ayoung
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0269-7491
e-ISSN:1873-6424
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:23 Apr 2020 14:35
Deposited On:23 Apr 2020 14:35

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