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An African origin for Mycobacterium bovis

Loiseau, Chloé and Menardo, Fabrizio and Aseffa, Abraham and Hailu, Elena and Gumi, Balako and Ameni, Gobena and Berg, Stefan and Rigouts, Leen and Robbe-Austerman, Suelee and Zinsstag, Jakob and Gagneux, Sebastien and Brites, Daniela. (2020) An African origin for Mycobacterium bovis. Evolution, medicine, and public health, 2020. pp. 49-59.

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Abstract

Mycobacterium bovis; and; Mycobacterium caprae; are two of the most important agents of tuberculosis in livestock and the most important causes of zoonotic tuberculosis in humans. However, little is known about the global population structure, phylogeography and evolutionary history of these pathogens.; We compiled a global collection of 3364 whole-genome sequences from; M.bovis; and; M.caprae; originating from 35 countries and inferred their phylogenetic relationships, geographic origins and age.; Our results resolved the phylogenetic relationship among the four previously defined clonal complexes of; M.bovis; , and another eight newly described here. Our phylogeographic analysis showed that; M.bovis; likely originated in East Africa. While some groups remained restricted to East and West Africa, others have subsequently dispersed to different parts of the world.; Our results allow a better understanding of the global population structure of; M.bovis; and its evolutionary history. This knowledge can be used to define better molecular markers for epidemiological investigations of; M.bovis; in settings where whole-genome sequencing cannot easily be implemented.; During the last few years, analyses of large globally representative collections of whole-genome sequences (WGS) from the human-adapted Mycobacterium tuberculosis complex (MTBC) lineages have enhanced our understanding of the global population structure, phylogeography and evolutionary history of these pathogens. In contrast, little corresponding data exists for M. bovis, the most important agent of tuberculosis in livestock. Using whole-genome sequences of globally distributed M. bovis isolates, we inferred the genetic relationships among different M. bovis genotypes distributed around the world. The most likely origin of M. bovis is East Africa according to our inferences. While some M. bovis groups remained restricted to East and West Africa, others have subsequently dispersed to different parts of the world driven by cattle movements.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Human and Animal Health > One Health (Zinsstag)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Research (Gagneux)
UniBasel Contributors:Loiseau, Chloé Marie and Menardo, Fabrizio and Zinsstag, Jakob Z and Gagneux, Sebastien and Brites, Daniela
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford Univ. Press
ISSN:2050-6201
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Identification Number:
Last Modified:07 Apr 2020 12:18
Deposited On:07 Apr 2020 12:18

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