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Comparing the lung cancer burden of ambient particulate matter using scenarios of air quality standards versus acceptable risk levels

Castro, Alberto and Götschi, Thomas and Achermann, Beat and Baltensperger, Urs and Buchmann, Brigitte and Felber Dietrich, Denise and Flückiger, Alexandre and Geiser, Marianne and Gälli Purghart, Brigitte and Gygax, Hans and Kutlar Joss, Meltem and Lüthi, Lara Milena and Probst-Hensch, Nicole and Strähl, Peter and Künzli, Nino. (2020) Comparing the lung cancer burden of ambient particulate matter using scenarios of air quality standards versus acceptable risk levels. International journal of public health, 65 (2). pp. 139-148.

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Official URL: https://edoc.unibas.ch/76133/

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Abstract

Ambient particulate matter (PM) is regulated with science-based air quality standards, whereas carcinogens are regulated with a number of "acceptable" cases. Given that PM is also carcinogenic, we identify differences between approaches.; We assessed the lung cancer deaths for Switzerland attributable to exposure to PM up to 10 µm (PM; 10; ) and to five particle-bound carcinogens. For PM; 10; , we used an epidemiological approach based on relative risks with four exposure scenarios compared to two counterfactual concentrations. For carcinogens, we used a toxicological approach based on unit risks with four exposure scenarios.; The lung cancer burden using concentrations from 2010 was 10-14 times larger for PM; 10; than for the five carcinogens. However, the burden depends on the underlying exposure scenarios, counterfactual concentrations and number of carcinogens. All scenarios of the toxicological approach for five carcinogens result in a lower burden than the epidemiological approach for PM; 10; .; Air quality standards-promoted so far by the WHO Air Quality Guidelines-provide a more appealing framework to guide health risk-oriented clean air policymaking than frameworks based on a number of "acceptable" cases.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Kutlar Joss, Meltem and Probst Hensch, Nicole and Künzli, Esther
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Birkhäuser
ISSN:1661-8556
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Mar 2020 08:51
Deposited On:27 Mar 2020 08:51

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