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Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats

Zabela, Volha and Sampath, Chethan and Oufir, Mouhssin and Butterweck, Veronika and Hamburger, Matthias. (2020) Single dose pharmacokinetics of intravenous 3,4-dihydroxyphenylacetic acid and 3-hydroxyphenylacetic acid in rats. Fitoterapia, 142. p. 104526.

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Official URL: https://edoc.unibas.ch/76072/

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Abstract

3,4-Dihydroxyphenylacetic acid (DOPAC) and 3-hydroxyphenylacetic acid (3-HPAA) are intestinal metabolites of the dietary flavonoid quercetin. DOPAC reportedly showed anxiolytic activity after i.p. administration in rats. The fate of these metabolites after consumption, and the pharmacological properties of 3-HPAA in the body are largely unknown. The aim of the current study was to characterize pharmacokinetic properties of DOPAC and 3-HPAA after intravenous bolus application in rats. UHPLC-MS/MS methods for quantification of DOPAC and 3-HPAA levels in lithium heparin Sprague Dawley rat plasma were developed and validated according to international regulatory guidelines. Non-compartmental and compartmental analyses were performed. Pharmacokinetic profiles of DOPAC and 3-HPAA followed a two-compartment body model, with a fast distribution into peripheral tissues (half-lives of 3.27–5.26 min) and rapid elimination from the body (half-lives of 18.4–33.3 min).
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Pharmazeutische Biologie (Hamburger)
UniBasel Contributors:Hamburger, Matthias and Zabela, Volha and Oufir, Mouhssin
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier Science
ISSN:0367-326X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Nov 2021 15:08
Deposited On:01 Nov 2021 15:08

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