Improved diffraction of antithrombin crystals grown in microgravity

Wardell, M. R. and Skinner, R. and Carter, D. C. and Twigg, P. D. and Abrahams, J. P.. (1997) Improved diffraction of antithrombin crystals grown in microgravity. Acta Crystallographica. Section D, Biological Crystallography, 53. pp. 622-625.

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Crystals of antithrombin were grown both on earth and in microgravity aboard US Space Shuttle Flight STS-67. The quality of crystals grown in both environments was highly variable and many could not be indexed. The microgravity crystals, however, generally diffracted better, as demonstrated by a novel procedure that estimates the resolution of the Bragg scatter from single diffraction images, without requiring knowledge of the cell dimensions of the crystal. Whereas the best earth-grown crystals never diffracted beyond 3 Angstrom resolution, the best microgravity crystal diffracted to 2.6 Angstrom. The improvement, demonstrated here by a comparison of 23 microgravity and 12 earth-grown crystals, is attributed to better ordered crystal growth in microgravity, although other factors may have contributed also.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nano-diffraction of Biological Specimen (Abrahams)
UniBasel Contributors:Abrahams, Jan Pieter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Nov 2020 14:44
Deposited On:05 Nov 2020 14:44

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