1PSI: Intact recombined alpha1-antitrypsin mutant PHE 51 to LEU

Abrahams, J. P. and Elliott, P. R. and Lomas, D. A. and Carrell, R. W.. (1996) 1PSI: Intact recombined alpha1-antitrypsin mutant PHE 51 to LEU. Worldwide Protein Data Bank. 1PSI.

Full text not available from this repository.

Official URL: https://edoc.unibas.ch/76002/

Downloads: Statistics Overview


The reactive site loop of the serpin family of serine proteinase inhibitors is flexible and can adopt a number of diverse conformations. A 2.9 A resolution structure of alpha 1-antitrypsin-the principal proteinase inhibitor in human plasma-shows the loop in a stable canonical conformation matching that found in all other families of serine proteinase inhibitors. This unexpected finding in the absence of loop insertion into the body of the molecule favours a two-stage mechanism of inhibition and provides a model for the heparin activation of antithrombin. The beta-pleated strand conformation of the loop also accounts for the polymerization of the serpins in disease and for their association with other beta-sheet structures, most notably the beta-amyloid of Alzheimer's disease.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nano-diffraction of Biological Specimen (Abrahams)
UniBasel Contributors:Abrahams, Jan Pieter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:24 Nov 2021 15:39
Deposited On:24 Nov 2021 15:39

Repository Staff Only: item control page