Structural and functional aspects of C1-Inhibitor

Bos, Ineke G. A. and Hack, C. Erik and Abrahams, Jan Pieter. (2002) Structural and functional aspects of C1-Inhibitor. Immunobiology, 205 (4-5). pp. 518-533.

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Official URL: https://edoc.unibas.ch/75979/

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C1-Inh is a serpin that inhibits serine proteases from the complement and the coagulation pathway. C1-Inh consists of a serpin domain and a unique N-terminal domain and is heavily glycosylated. Nonfunctional mutants of C1-Inh can give insight into the inhibitory mechanism of C1-Inh. This review describes a novel 3D model of C1-Inh, based on a newly developed homology modelling method. This model gives insight into a possible potentiation mechanism of C1-Inh and based on this model the essential residues for efficient inhibition by C1-Inh are discussed.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nano-diffraction of Biological Specimen (Abrahams)
UniBasel Contributors:Abrahams, Jan Pieter
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Nov 2020 15:25
Deposited On:05 Nov 2020 15:25

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