The Aβ peptide forms non-amyloid fibrils in the presence of carbon nanotubes

Luo, Jinghui and Wärmländer, Sebastian K. T. S. and Chien-Hung, Yu and Muhammad, Kamran and Gräslund, Astrid and Abrahams, Jan Pieter. (2014) The Aβ peptide forms non-amyloid fibrils in the presence of carbon nanotubes. Nanoscale, 6 (12). pp. 6720-6726.

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Official URL: https://edoc.unibas.ch/75901/

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Carbon nanotubes have specific properties that make them potentially useful in biomedicine and biotechnology. However, carbon nanotubes may themselves be toxic, making it imperative to understand how carbon nanotubes interact with biomolecules such as proteins. Here, we used NMR, CD, and ThT/fluorescence spectroscopy together with AFM imaging to study pH-dependent molecular interactions between single walled carbon nanotubes (SWNTs) and the amyloid-beta (Abeta) peptide. The aggregation of the Abeta peptide, first into oligomers and later into amyloid fibrils, is considered to be the toxic mechanism behind Alzheimer's disease. We found that SWNTs direct the Abeta peptides to form a new class of beta-sheet-rich yet non-amyloid fibrils.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nano-diffraction of Biological Specimen (Abrahams)
UniBasel Contributors:Abrahams, Jan Pieter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Royal Society of Chemistry
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Nov 2020 08:27
Deposited On:06 Nov 2020 08:27

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