Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses

Fallet, Bénédict and Hao, Yi and Florova, Marianna and Cornille, Karen and de Los Aires, Alba Verge and Girelli Zubani, Giulia and Ertuna, Yusuf I. and Greiff, Victor and Menzel, Ulrike and Hammad, Karim and Merkler, Doron and Reddy, Sai T. and Weill, Jean-Claude and Reynaud, Claude-Agnès and Pinschewer, Daniel D.. (2020) Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses. Cell Reports, 30 (4). pp. 1013-1026.e7.

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Official URL: https://edoc.unibas.ch/75770/

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Persistent viral infections subvert key elements of adaptive immunity. To compare germinal center (GC) B cell responses in chronic and acute lymphocytic choriomeningitis virus infection, we exploit activation-induced deaminase (AID) fate-reporter mice and perform adoptive B cell transfer experiments. Chronic infection yields GC B cell responses of higher cellularity than acute infections do, higher memory B cell and antibody secreting cell output for longer periods of time, a better representation of the late B cell repertoire in serum immunoglobulin, and higher titers of protective neutralizing antibodies. GC B cells of chronically infected mice are similarly hypermutated as those emerging from acute infection. They efficiently adapt to viral escape variants and even in hypermutation-impaired AID mutant mice, chronic infection selects for GC B cells with hypermutated B cell receptors (BCRs) and neutralizing antibody formation. These findings demonstrate that, unlike for CD8; +; T cells, chronic viral infection drives a functional, productive, and protective GC B cell response.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Medical Microbiology > Experimental Virology (Pinschewer)
UniBasel Contributors:Pinschewer, Daniel and Fallet, Bénédict and Florova, Marianna and Cornille, Karen
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Cell Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:26 Jul 2023 13:09
Deposited On:30 Dec 2020 08:39

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