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Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles

He, Jingjing and Sinues, Pablo Martinez-Lozano and Hollmén, Maija and Li, Xue and Detmar, Michael and Zenobi, Renato. (2014) Fingerprinting breast cancer vs. normal mammary cells by mass spectrometric analysis of volatiles. Scientific Reports, 4. p. 5196.

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Official URL: https://edoc.unibas.ch/75584/

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Abstract

There is increasing interest in the development of noninvasive diagnostic methods for early cancer detection, to improve the survival rate and quality of life of cancer patients. Identification of volatile metabolic compounds may provide an approach for noninvasive early diagnosis of malignant diseases. Here we analyzed the volatile metabolic signature of human breast cancer cell lines versus normal human mammary cells. Volatile compounds in the headspace of conditioned culture medium were directly fingerprinted by secondary electrospray ionization-mass spectrometry. The mass spectra were subsequently treated statistically to identify discriminating features between normal vs. cancerous cell types. We were able to classify different samples by using feature selection followed by principal component analysis (PCA). Additionally, high-resolution mass spectrometry allowed us to propose their chemical structures for some of the most discriminating molecules. We conclude that cancerous cells can release a characteristic odor whose constituents may be used as disease markers.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedical Engineering > Imaging and Computational Modelling > Translational Medicine Breath Research (Sinues)
UniBasel Contributors:Sinues, Pablo
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Nature Publishing Group
e-ISSN:2045-2322
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:01 Jun 2020 08:06
Deposited On:01 Jun 2020 08:06

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