Nuclear size control in fission yeast

Neumann, Frank R. and Nurse, Paul. (2007) Nuclear size control in fission yeast. Journal of Cell Biology, 179 (4). pp. 593-600.

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Official URL: https://edoc.unibas.ch/75465/

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A long-standing biological question is how a eukaryotic cell controls the size of its nucleus. We report here that in fission yeast, nuclear size is proportional to cell size over a 35-fold range, and use mutants to show that a 16-fold change in nuclear DNA content does not influence the relative size of the nucleus. Multi-nucleated cells with unevenly distributed nuclei reveal that nuclei surrounded by a greater volume of cytoplasm grow more rapidly. During interphase of the cell cycle nuclear growth is proportional to cell growth, and during mitosis there is a rapid expansion of the nuclear envelope. When the nuclear/cell (N/C) volume ratio is increased by centrifugation or genetic manipulation, nuclear growth is arrested while the cell continues to grow; in contrast, low N/C ratios are rapidly corrected by nuclear growth. We propose that there is a general cellular control linking nuclear growth to cell size.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin
UniBasel Contributors:Neumann, Frank R.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Rockefeller University Press
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Nov 2020 10:48
Deposited On:06 Nov 2020 10:48

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